Arsene Wenger’s side currently sit 4th in the league, but are 12 points adrift of league leaders Manchester City.
City’s neighbours, Manchester United are second. Jose Mourinho’s side dispatched Watford on Tuesday night to extend the gap back to Arsenal to seven.
Last weekend’s added time winner over Burnley has lifted Wenger’s side above Tottenham and the Gunners can increase the gap and strengthen their place in the top four with victory.
Arsenal will be hoping Mesut Ozil is available. The German has been suffering with another illness, but the club are optimistic he has recovered in time.
Alex Iwobi (leg) is definitely out, as is long-term injury absentee Santi Cazorla (ankle), but they are Arsene Wenger’s only two sidelined players.
As for the visitors, David Wagner will be without suspended winger Rajiv Van la Parra, who starts a three-match ban following his red card in Sunday’s home defeat to Manchester City.
Despite the 2-1 defeat, the promoted side are currently sitting pretty in 13th in the league.
The Gunners have been formidable at home, but will need to be wary of the Terriers on the counter-attack.
PREDICTED ARSENAL XI
Gooners have been calling for Jack Wilshere to start, particularly after influencing the game as a substitute last weekend.
However, Arsene Wenger is likely to pursue with Aaron Ramsey and Granit Xhaka as his midfield duo. With Alex Iwobi missing, Mesut Ozil is in line to start. Should the German not be ready to return, expect Danny Welbeck to be given the nod.
The promoted side have been impressive this season, but have largely relied on their home form for Premier League points.
Arsenal meanwhile are formidable at the Emirates, winning their last 11 league games in front of their fans.
Gooners, what do you think the score will be? Let us know in the comments…