The Gunners are already through to the next round as Group H winners and have done so without turning to several of their first-team players.
Youngsters Ben Sheaf, Eddie Nketiah and Matt Macey have all signed new longterm deals, but the trio may be made to wait until Arsenal’s League Cup quarter-final tie on December 19 for game time.
Arsenal could be drawn against Borussia Dortmund or Atletico Madrid in the later stages after both teams dropped out of the Champions League.
Olivier Giroud, Jack Wilshere and Theo Walcott are in line for starts. The trio have not started a Premier League match between them so far, but have played regularly in the Europa League.
France international coach Guy Stephan has warned Giroud that he needs to consider his future if he expects to picked for the World Cup squad.
Meanwhile, Walcott has not appeared for Arsenal since the 0-0 draw with Red Star Belgrade on November 2 after being sidelined with illness for a fortnight.
PREDICTED ARSENAL XI
Wenger claims he will deploy an experienced side. However, you can still expect the Arsenal boss to use the fixture to field a number of his youngsters.
Mohamed Elneny could feature, while Reiss Nelson, Joe Willock and Ainsley Maitland-Niles have all been ever present this term.
Mattieu Debuchy is also expected to continue quietly continue his comeback.
Arsenal XI: Ospina; Debuchy, Elneny, Holding, Maitland-Niles, Nelson; Willock, Elneny; Wilshere, Walcott, Giroud.
Arsenal’s defeat in Cologne and goalless draw against Red Star Belgrade shouldn’t affect the confidence of the side.
Having put four passed BATE in the reverse fixture, Gooners can expect a similar performance tonight.
Gooners, what do you think the score will be? Let us know in the comments…